{"id":25859,"date":"2025-03-11T14:13:54","date_gmt":"2025-03-11T19:13:54","guid":{"rendered":"https:\/\/www.ataxia.org\/?p=25859"},"modified":"2025-05-02T11:13:19","modified_gmt":"2025-05-02T16:13:19","slug":"2025-naf-research-grants","status":"publish","type":"post","link":"https:\/\/www.ataxia.org\/2025-naf-research-grants\/","title":{"rendered":"2025 NAF Research Grants"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"25859\" class=\"elementor elementor-25859\" data-elementor-post-type=\"post\">\n\t\t\t\t<div class=\"elementor-element elementor-element-69d0c7b e-flex e-con-boxed e-con e-parent\" data-id=\"69d0c7b\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-62d2662 elementor-widget elementor-widget-image\" data-id=\"62d2662\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"640\" height=\"335\" src=\"https:\/\/www.ataxia.org\/wp-content\/uploads\/2025\/03\/Funded-Research-Featured-Image-1024x536.png\" class=\"attachment-large size-large wp-image-25861\" alt=\"\" srcset=\"https:\/\/www.ataxia.org\/wp-content\/uploads\/2025\/03\/Funded-Research-Featured-Image-1024x536.png 1024w, https:\/\/www.ataxia.org\/wp-content\/uploads\/2025\/03\/Funded-Research-Featured-Image-300x157.png 300w, https:\/\/www.ataxia.org\/wp-content\/uploads\/2025\/03\/Funded-Research-Featured-Image-768x402.png 768w, https:\/\/www.ataxia.org\/wp-content\/uploads\/2025\/03\/Funded-Research-Featured-Image.png 1200w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-c4eaf82 e-flex e-con-boxed e-con e-parent\" data-id=\"c4eaf82\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-8b22f25 elementor-widget elementor-widget-spacer\" data-id=\"8b22f25\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-d8b19fa elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"d8b19fa\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-a548866\" data-id=\"a548866\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-71acaba elementor-widget elementor-widget-text-editor\" data-id=\"71acaba\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>We&#8217;re proud to announce that we funded 18 research grants for 2025 totaling $730K!&nbsp;<\/p><p><span style=\"color: var( --e-global-color-text ); font-family: var( --e-global-typography-text-font-family ), Sans-serif;\">For the funding term of March 1, 2025 &#8211; February 28, 2026,&nbsp;<\/span><span style=\"color: var( --e-global-color-text ); font-family: var( --e-global-typography-text-font-family ), Sans-serif;\">NAF received 96 Letters of Intent and 33 grant applications. ~50 scientific reviewers scored full applications, assigning a score between 1.0 and 5.0 (1= outstanding) for the following categories:<\/span><\/p>\n<ul>\n<li>Scientific Merit<\/li>\n<li>Innovation<\/li>\n<li>Impact<\/li>\n<li>Overall<\/li>\n<\/ul>\n<div>\n<p>Reviewers also provide written feedback on feasibility (budget &amp; timeline), and alignment with NAF mission.&nbsp;<\/p>\n<\/div>\n<p><b>We&#8217;d like to give a huge kudos to our scientific reviewers who volunteer their time and expertise to make sure that the best science to accelerate Ataxia treatment development is funded!&nbsp;<\/b><\/p>\n<h3>For 2025, NAF funded the following research:<\/h3>\n<ul>\n<li><b>7 Research Seed Money Grants<\/b>&nbsp;&#8211; totaling $350,000<\/li>\n<li><b>3 Early Career Investigator Awards <\/b>&#8211; totaling $150,000<\/li>\n<li><b>5 Graduate Research Fellowships<\/b> &#8211; totaling $125,000<\/li>\n<li><b style=\"color: var( --e-global-color-text ); font-family: var( --e-global-typography-text-font-family ), Sans-serif;\">3 Post-Doctoral Fellowship<\/b><span style=\"color: var( --e-global-color-text ); font-family: var( --e-global-typography-text-font-family ), Sans-serif; font-weight: var( --e-global-typography-text-font-weight );\"> &#8211; totaling $105,000<\/span><\/li>\n<\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-a8df41b elementor-widget elementor-widget-spacer\" data-id=\"a8df41b\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t<div class=\"elementor-element elementor-element-7aeff3d e-flex e-con-boxed e-con e-parent\" data-id=\"7aeff3d\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-8f5865e elementor-widget elementor-widget-image\" data-id=\"8f5865e\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"640\" height=\"387\" src=\"https:\/\/www.ataxia.org\/wp-content\/uploads\/2025\/03\/2025-Funded-Research.png\" class=\"attachment-large size-large wp-image-25862\" alt=\"\" srcset=\"https:\/\/www.ataxia.org\/wp-content\/uploads\/2025\/03\/2025-Funded-Research.png 642w, https:\/\/www.ataxia.org\/wp-content\/uploads\/2025\/03\/2025-Funded-Research-300x181.png 300w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-341089b elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"341089b\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-8d0edce\" data-id=\"8d0edce\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-2755648 elementor-widget elementor-widget-text-editor\" data-id=\"2755648\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>\u00a0<\/p><p>To learn more about each type of research study, visit <span style=\"text-decoration: underline;\"><strong><a href=\"https:\/\/www.ataxia.org\/researcher-resources\/\">www.ataxia.org\/researcher-resources.<\/a><\/strong><\/span><\/p><p>A full list of the research studies and their lay summaries are available below.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-d53c7ad elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"d53c7ad\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ea31c36 elementor-widget elementor-widget-heading\" data-id=\"ea31c36\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Lay Summaries<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-23f6a43 elementor-widget elementor-widget-spacer\" data-id=\"23f6a43\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-47e1eb3 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"47e1eb3\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-7a8c7b8\" data-id=\"7a8c7b8\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-e5247fb elementor-widget elementor-widget-heading\" data-id=\"e5247fb\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">Research Seed Money Grants<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-eae348e elementor-widget elementor-widget-text-editor\" data-id=\"eae348e\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>$50,000 &#8211; 1-Year Grant<br \/>48 LOIs Received | 13 Full Applications Reviewed | 7 Funded<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-686262b elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"686262b\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-33 elementor-top-column elementor-element elementor-element-d72294c\" data-id=\"d72294c\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-f1e09e9 elementor-widget elementor-widget-image\" data-id=\"f1e09e9\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"400\" height=\"500\" src=\"https:\/\/www.ataxia.org\/wp-content\/uploads\/2025\/03\/Geoffrey-Abbott-Sized.png\" class=\"attachment-large size-large wp-image-25869\" alt=\"\" srcset=\"https:\/\/www.ataxia.org\/wp-content\/uploads\/2025\/03\/Geoffrey-Abbott-Sized.png 400w, https:\/\/www.ataxia.org\/wp-content\/uploads\/2025\/03\/Geoffrey-Abbott-Sized-240x300.png 240w\" sizes=\"(max-width: 400px) 100vw, 400px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-d53ad9e elementor-widget elementor-widget-text-editor\" data-id=\"d53ad9e\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"color: #005587;\"><b>Dr. Geoffrey Abbott<br \/><\/b><\/span>The Regents of the University of California, Irvine <br \/><br \/><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-66 elementor-top-column elementor-element elementor-element-bccb713\" data-id=\"bccb713\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-b0cea3d elementor-widget elementor-widget-text-editor\" data-id=\"b0cea3d\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>Research Title:<\/strong><em> Small molecule therapeutic development for Episodic Ataxia 1 <br \/><\/em><\/p><p><b>Ataxia Type: <\/b>EA1<\/p><p>Episodic ataxias are debilitating movement disorders often also associated with a constellation of additional pathologies. We recently drew from Native American traditional medicine approaches to identify several plant metabolites that reverse the cellular effects of episodic ataxia-linked gene variants. In this pilot project, we will test the efficacy and safety of these promising compounds in a rodent model of human Episodic Ataxia Type 1, with the goal of preparing for future clinical trials. .<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-6464269 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"6464269\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-47f4627\" data-id=\"47f4627\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-e886ed9 elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"e886ed9\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-f17a04a elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"f17a04a\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-33 elementor-top-column elementor-element elementor-element-77370af\" data-id=\"77370af\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-78a9adf elementor-widget elementor-widget-image\" data-id=\"78a9adf\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"400\" height=\"500\" src=\"https:\/\/www.ataxia.org\/wp-content\/uploads\/2025\/03\/Aquizu-Lopez-Sized.png\" class=\"attachment-large size-large wp-image-25864\" alt=\"\" srcset=\"https:\/\/www.ataxia.org\/wp-content\/uploads\/2025\/03\/Aquizu-Lopez-Sized.png 400w, https:\/\/www.ataxia.org\/wp-content\/uploads\/2025\/03\/Aquizu-Lopez-Sized-240x300.png 240w\" sizes=\"(max-width: 400px) 100vw, 400px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-067ef41 elementor-widget elementor-widget-text-editor\" data-id=\"067ef41\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"color: #005587;\"><b>Dr. Naiara Aquizu Lopez<br \/><\/b><\/span>The Children\u2019s Hospital of Philadelphia<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-66 elementor-top-column elementor-element elementor-element-d584ed5\" data-id=\"d584ed5\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-6956517 elementor-widget elementor-widget-text-editor\" data-id=\"6956517\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>Research Title:<\/strong><em> Uncovering a novel recessive spinocerebellar ataxia caused by genetic variants in SNX13 <br \/><\/em><\/p><p><b>Ataxia Type: <\/b>SCAR20<\/p><p>Disturbed lipid regulation is emerging as a major cause of recessive spinocerebellar ataxias, but mechanisms that lead to disease remain unknown. We recently uncovered a novel group of spinocerebellar ataxias caused by genetic mutations in putative lipid transport proteins. Capitalizing on these discoveries, our project aims to elucidate why the cerebellum is particularly vulnerable to lipid dysregulation and to establish the genetic diagnosis for a previously undefined group of recessive spinocerebellar ataxias.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-90c8a55 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"90c8a55\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-4c7c065\" data-id=\"4c7c065\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-6ee2e56 elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"6ee2e56\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-6399090 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"6399090\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-33 elementor-top-column elementor-element elementor-element-2649139\" data-id=\"2649139\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-6991425 elementor-widget elementor-widget-image\" data-id=\"6991425\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"400\" height=\"500\" src=\"https:\/\/www.ataxia.org\/wp-content\/uploads\/2025\/03\/Nicholas-Brown-Sized.png\" class=\"attachment-large size-large wp-image-25878\" alt=\"\" srcset=\"https:\/\/www.ataxia.org\/wp-content\/uploads\/2025\/03\/Nicholas-Brown-Sized.png 400w, https:\/\/www.ataxia.org\/wp-content\/uploads\/2025\/03\/Nicholas-Brown-Sized-240x300.png 240w\" sizes=\"(max-width: 400px) 100vw, 400px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-5d3ad02 elementor-widget elementor-widget-text-editor\" data-id=\"5d3ad02\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"color: #005587;\"><b>Dr. Nicholas Brown<br \/><\/b><\/span>University of North Carolina at Chapel Hill <br \/><br \/><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-66 elementor-top-column elementor-element elementor-element-ce9381f\" data-id=\"ce9381f\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-ac734a7 elementor-widget elementor-widget-text-editor\" data-id=\"ac734a7\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>Research Title:<\/strong><em> Deciphering the link between mRNA regulation and protein degradation in PUM1-related ataxias, PADDAS and PRCA <br \/><\/em><\/p><p><b>Ataxia Type: <\/b>SCA47<\/p><p>In spinocerebellar ataxia-47 (SCA47), mutations in the PUM1 gene can result in two distinct syndromes: Pumilio1-Associated Developmental Delay and Seizures (PADDAS) and Pumilio1-Related Cerebellar Ataxia (PRCA). To date, most studies have focused on how different mutations in PUM1 lead to varying phenotypes; but it is currently unclear how PUM1 is regulated. A deeper understanding of this process may be key to uncovering the physiological role of PUM1 in the brain..<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-a895cec elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"a895cec\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-ac08fc1\" data-id=\"ac08fc1\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-c6fe3d8 elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"c6fe3d8\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-e525d06 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"e525d06\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-33 elementor-top-column elementor-element elementor-element-26eab97\" data-id=\"26eab97\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-8a23369 elementor-widget elementor-widget-image\" data-id=\"8a23369\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"400\" height=\"500\" src=\"https:\/\/www.ataxia.org\/wp-content\/uploads\/2025\/03\/Gros-Louis-Sized.png\" class=\"attachment-large size-large wp-image-25870\" alt=\"\" srcset=\"https:\/\/www.ataxia.org\/wp-content\/uploads\/2025\/03\/Gros-Louis-Sized.png 400w, https:\/\/www.ataxia.org\/wp-content\/uploads\/2025\/03\/Gros-Louis-Sized-240x300.png 240w\" sizes=\"(max-width: 400px) 100vw, 400px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-a170321 elementor-widget elementor-widget-text-editor\" data-id=\"a170321\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"color: #005587;\"><b>Dr. Francois Gros-Louis<br \/><\/b><\/span><span class=\"TextRun SCXW123685366 BCX0\" lang=\"EN-US\" xml:lang=\"EN-US\" data-contrast=\"auto\"><span class=\"NormalTextRun SCXW123685366 BCX0\">Laval University<\/span><\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-66 elementor-top-column elementor-element elementor-element-49df00c\" data-id=\"49df00c\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-e4f7ba1 elementor-widget elementor-widget-text-editor\" data-id=\"e4f7ba1\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>Research Title:<\/strong><em> Generation of patient-derived Isogenic iPSC Lines of ARSACS Patients: A Critical Resource for Therapeutic Development<\/em><\/p><p><b>Ataxia Type: <\/b>ARSACS<\/p><p>This project aims to advance the understanding and treatment of Autosomal Recessive Spastic Ataxia of Charlevoix-Saguenay (ARSACS) by generating patient-derived induced pluripotent stem cells (iPSCs) and using CRISPR-Cas9 gene correction to create isogenic models. This initiative will provide valuable tools for the scientific community, accelerating drug discovery and fostering collaborative efforts to develop effective treatments for ARSACS and related genetic disorders.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-add7c66 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"add7c66\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-a94d76f\" data-id=\"a94d76f\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-67a750c elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"67a750c\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-b1584fb elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"b1584fb\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-33 elementor-top-column elementor-element elementor-element-eb9727a\" data-id=\"eb9727a\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-44f9863 elementor-widget elementor-widget-image\" data-id=\"44f9863\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"400\" height=\"500\" src=\"https:\/\/www.ataxia.org\/wp-content\/uploads\/2025\/03\/Angela-Laird-Sized.png\" class=\"attachment-large size-large wp-image-25863\" alt=\"\" srcset=\"https:\/\/www.ataxia.org\/wp-content\/uploads\/2025\/03\/Angela-Laird-Sized.png 400w, https:\/\/www.ataxia.org\/wp-content\/uploads\/2025\/03\/Angela-Laird-Sized-240x300.png 240w\" sizes=\"(max-width: 400px) 100vw, 400px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-f03394b elementor-widget elementor-widget-text-editor\" data-id=\"f03394b\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"color: #005587;\"><b>Dr. Angela Laird<br \/><\/b><\/span>Macquarie University<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-66 elementor-top-column elementor-element elementor-element-15736d4\" data-id=\"15736d4\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-0cc777d elementor-widget elementor-widget-text-editor\" data-id=\"0cc777d\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>Research Title:<\/strong><em> Understanding the role of cellular energetics and the gut-brain axis in MJD<\/em><\/p><p><b>Ataxia Type: <\/b>SCA3<\/p><p>We have recently identified that the composition of the gut microbiome of a transgenic mouse model of SCA3\/MJD is different to that of litter-mate control mice, even at ages prior to the onset of motor symptoms. Furthermore, we have identified that these mice develop altered gastrointestinal function. These changes have not been explored before. In this study, we will investigate the underlying causes of these changes and the effects of modifying underlying mechanisms.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-6f600e3 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"6f600e3\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-d690850\" data-id=\"d690850\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-ac6a022 elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"ac6a022\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-7f74e72 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"7f74e72\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-33 elementor-top-column elementor-element elementor-element-697147e\" data-id=\"697147e\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-1c63be1 elementor-widget elementor-widget-image\" data-id=\"1c63be1\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"400\" height=\"500\" src=\"https:\/\/www.ataxia.org\/wp-content\/uploads\/2025\/03\/Maltecca-Sized.png\" class=\"attachment-large size-large wp-image-25876\" alt=\"\" srcset=\"https:\/\/www.ataxia.org\/wp-content\/uploads\/2025\/03\/Maltecca-Sized.png 400w, https:\/\/www.ataxia.org\/wp-content\/uploads\/2025\/03\/Maltecca-Sized-240x300.png 240w\" sizes=\"(max-width: 400px) 100vw, 400px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-5587204 elementor-widget elementor-widget-text-editor\" data-id=\"5587204\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"color: #005587;\"><b>Dr. Francesca Maltecca<br \/><\/b><\/span>San Raffaele Hospital<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-66 elementor-top-column elementor-element elementor-element-36cd84f\" data-id=\"36cd84f\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-eb8c7d1 elementor-widget elementor-widget-text-editor\" data-id=\"eb8c7d1\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>Research Title:<\/strong><em> Testing a gene therapy approach in the spastic ataxia type 5 (SPAX5) mouse model<br \/><\/em><\/p><p><b>Ataxia Type: <\/b>SPAX5<\/p><p>Spastic ataxia type 5 (SPAX5) is a severe form of childhood-onset ataxia, associated with spasticity and epilepsy. It is caused by mutations in the <em>AFG3L2<\/em> gene which encodes the homonymous protein AFG3L2, which resides in the mitochondrion and is essential for protein quality control, energy production and regulation of mitochondrial morphology. In agreement, we observed energy failure and altered mitochondrial morphology as key features SPAX5, demonstrated by our studies in cells derived from patients and in mouse models.<\/p><p>We recently analyzed cells derived from SPAX5 patients and we found that the levels of AFG3L2 protein are strikingly reduced. This disease represents therefore an ideal condition to test a gene replacement therapy based on adeno-associated viral (AAV) vectors. AAVs up to now represent the most promising and safest gene delivery tools for clinical trials, and have been successfully employed for severe neurodegenerative diseases. This encouraging data support a similar approach for treating SPAX5 with early intervention and a specific site of administration strategy, considering the seriousness and time of onset of this devastating recessive disease.<\/p><p>Based on promising preliminary data, the goal of our proposal is to investigate a gene-based therapeutic strategy to restore sufficient levels of AFG3L2 protein in the cerebellum and other neuronal systems, seeking to correct the ataxic phenotype and the mitochondrial dysfunction of the <em>Afg3l2<sup>-\/-<\/sup><\/em> mouse. The results obtained by our studies may open new perspectives for the treatment of SPAX5, for which a cure is still an unmet need.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-927a078 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"927a078\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-a03130d\" data-id=\"a03130d\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-370cd20 elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"370cd20\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-fe113c7 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"fe113c7\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-33 elementor-top-column elementor-element elementor-element-60881d6\" data-id=\"60881d6\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-7c7417c elementor-widget elementor-widget-image\" data-id=\"7c7417c\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"400\" height=\"500\" src=\"https:\/\/www.ataxia.org\/wp-content\/uploads\/2025\/03\/Stephan-Zuchner-Sized.png\" class=\"attachment-large size-large wp-image-25879\" alt=\"\" srcset=\"https:\/\/www.ataxia.org\/wp-content\/uploads\/2025\/03\/Stephan-Zuchner-Sized.png 400w, https:\/\/www.ataxia.org\/wp-content\/uploads\/2025\/03\/Stephan-Zuchner-Sized-240x300.png 240w\" sizes=\"(max-width: 400px) 100vw, 400px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-1ccbd40 elementor-widget elementor-widget-text-editor\" data-id=\"1ccbd40\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"color: #005587;\"><b>Dr. Stephan Zuchner<br \/><\/b><\/span>Miller School of Medicine at the University of Miami <br \/><br \/><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-66 elementor-top-column elementor-element elementor-element-e3a5470\" data-id=\"e3a5470\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-5043146 elementor-widget elementor-widget-text-editor\" data-id=\"5043146\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>Research Title:<\/strong><em> Creating a rodent RGR14 GAA repeat expansion model as a translational platform for SCA27B <br \/><\/em><\/p><p><b>Ataxia Type: <\/b>SCA27B<\/p><p>The goal of this project is to create a rat animal model that will mimic the pathogenic DNA changes seen in people with SCA27B. Such an animal model, once characterized, will represent a valuable platform to further study the disease pathology and also to safely and efficiently test new treatments for this form of ataxia. For that reason the animal will be \u2018humanized\u2019 at the SCA27B locus, containing human DNA stretches, which will allow the testing of genetic therapy approaches, such as ASO or CRISPR\/Cas9.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-1346b52 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"1346b52\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-9f30d75\" data-id=\"9f30d75\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-efa8a0c elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"efa8a0c\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-9c262af elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"9c262af\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-63d592a\" data-id=\"63d592a\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-bbe4fc8 elementor-widget elementor-widget-heading\" data-id=\"bbe4fc8\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">Early Career Investigator Awards<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-89bbb6a elementor-widget elementor-widget-text-editor\" data-id=\"89bbb6a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>$50,000 &#8211; 1-Year Grant<br \/>14 LOIs Received | 6 Full Applications Reviewed | 3 Funded<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-d62a23c elementor-widget elementor-widget-spacer\" data-id=\"d62a23c\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-c1189f1 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"c1189f1\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-33 elementor-top-column elementor-element elementor-element-dc95e60\" data-id=\"dc95e60\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-f7364bd elementor-widget elementor-widget-image\" data-id=\"f7364bd\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"400\" height=\"500\" src=\"https:\/\/www.ataxia.org\/wp-content\/uploads\/2025\/03\/Joanna-Korecka-Roet-Sized.png\" class=\"attachment-large size-large wp-image-25873\" alt=\"\" srcset=\"https:\/\/www.ataxia.org\/wp-content\/uploads\/2025\/03\/Joanna-Korecka-Roet-Sized.png 400w, https:\/\/www.ataxia.org\/wp-content\/uploads\/2025\/03\/Joanna-Korecka-Roet-Sized-240x300.png 240w\" sizes=\"(max-width: 400px) 100vw, 400px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-db93fbe elementor-widget elementor-widget-text-editor\" data-id=\"db93fbe\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"color: #005587;\"><b>Dr. Joanna Korecka-Roet<br \/><\/b><\/span><span class=\"TextRun SCXW67189192 BCX0\" lang=\"EN-US\" xml:lang=\"EN-US\" data-contrast=\"auto\"><span class=\"NormalTextRun SCXW67189192 BCX0\">Brigham and Women\u2019s Hospital, Inc.<\/span><\/span><span class=\"LineBreakBlob BlobObject DragDrop SCXW67189192 BCX0\"><span class=\"SCXW67189192 BCX0\">\u00a0<\/span><\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-66 elementor-top-column elementor-element elementor-element-6d36b28\" data-id=\"6d36b28\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-5f1559d elementor-widget elementor-widget-text-editor\" data-id=\"5f1559d\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>Research Title:<\/strong><em> Restoring disrupted DRPLA neuronal activity through genetic medicine <br \/><\/em><\/p><p><b>Ataxia Type: <\/b>DRPLA<\/p><p>DRPLA is a rare, genetic, progressive brain disorder that causes ataxia, dementia and epilepsy, the latter particularly affecting young patients. Currently, no treatments are available. In this study, we aim to enhance our existing brain cell models that use stem cells from DRPLA patients to mimic the epilepsy-related changes \u2018in a dish.\u2019 We will also explore how astrocytes, the brain&#8217;s supportive cells, affect brain-cell activity in this disease. Using this model, we will test whether two new genetic therapies can correct the abnormal brain activity caused by this condition.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-296cce5 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"296cce5\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-89af6d7\" data-id=\"89af6d7\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-6f1a259 elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"6f1a259\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-665ef1c elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"665ef1c\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-33 elementor-top-column elementor-element elementor-element-4445f31\" data-id=\"4445f31\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-e533e58 elementor-widget elementor-widget-image\" data-id=\"e533e58\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"400\" height=\"500\" src=\"https:\/\/www.ataxia.org\/wp-content\/uploads\/2025\/03\/Tatsuaki-L-Sized.png\" class=\"attachment-large size-large wp-image-25880\" alt=\"\" srcset=\"https:\/\/www.ataxia.org\/wp-content\/uploads\/2025\/03\/Tatsuaki-L-Sized.png 400w, https:\/\/www.ataxia.org\/wp-content\/uploads\/2025\/03\/Tatsuaki-L-Sized-240x300.png 240w\" sizes=\"(max-width: 400px) 100vw, 400px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-08a2bb5 elementor-widget elementor-widget-text-editor\" data-id=\"08a2bb5\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"color: #005587;\"><b>Dr. Tatsuaki Kurosaki<br \/><\/b><\/span>Jacobs School of Medicine and Biomedical Sciences<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-66 elementor-top-column elementor-element elementor-element-3caff1a\" data-id=\"3caff1a\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-279bf42 elementor-widget elementor-widget-text-editor\" data-id=\"279bf42\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>Research Title:<\/strong><em> RNA Misregulation in Spinocerebellar Ataxia Type 10 Cells <br \/><\/em><\/p><p><b>Ataxia Type: <\/b>SCA10<\/p><p>Spinocerebellar ataxia type 10 (SCA10) is an inherited neurodegenerative disorder that causes progressive ataxia, seizures, cognitive impairment, and peripheral neuropathy. Preliminary transcriptome and proteome analyses suggest that SCA10 involves disruptions in RNA metabolism, misregulation of essential RNA-binding proteins, and interference with normal cellular functions. By studying multiple SCA10 cell models, we aim to further clarify the disease mechanism and contribute to the development of effective treatments.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-336bdd0 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"336bdd0\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-530a89c\" data-id=\"530a89c\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-c660cb4 elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"c660cb4\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-3f1e832 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"3f1e832\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-33 elementor-top-column elementor-element elementor-element-45c89cb\" data-id=\"45c89cb\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-3cb5268 elementor-widget elementor-widget-image\" data-id=\"3cb5268\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"400\" height=\"500\" src=\"https:\/\/www.ataxia.org\/wp-content\/uploads\/2025\/03\/Mafalda-Raposo-Sized.png\" class=\"attachment-large size-large wp-image-25875\" alt=\"\" srcset=\"https:\/\/www.ataxia.org\/wp-content\/uploads\/2025\/03\/Mafalda-Raposo-Sized.png 400w, https:\/\/www.ataxia.org\/wp-content\/uploads\/2025\/03\/Mafalda-Raposo-Sized-240x300.png 240w\" sizes=\"(max-width: 400px) 100vw, 400px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-13859cd elementor-widget elementor-widget-text-editor\" data-id=\"13859cd\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"color: #005587;\"><b>Dr. Mafalda Raposo<br \/><\/b><\/span>i3S- Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade da Universidade do Porto <br \/><br \/><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-66 elementor-top-column elementor-element elementor-element-a9cb710\" data-id=\"a9cb710\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-2fee2d2 elementor-widget elementor-widget-text-editor\" data-id=\"2fee2d2\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>Research Title:<\/strong><em> Deciphering the role of long noncoding ATXN3 RNAs in Machado-Joseph disease\/spinocerebellar ataxia type 3 (MJD\/SCA3) pathogenesis <br \/><\/em><\/p><p><b>Ataxia Type: <\/b>SCA3<\/p><p>Machado-Joseph Disease (MJD) also known as spinocerebellar ataxia type 3 (SCA3), is caused by a mutation in the <em>ATXN3<\/em> gene. <em>ATXN3<\/em> produces various forms of an RNA molecule known as alternative transcripts. Around 40% of these RNAs are expected to be long noncoding RNAs (lncRNAs). These lncRNAs do not create proteins but might help control gene expression. It\u2019s still uncertain whether these lncRNAs have a protective role or contribute to MJD pathogenesis. Our recent research found three <em>ATXN3<\/em> lncRNAs that may play a role in the disease process, but their precise function remains unclear.<\/p><p>This project will investigate several questions about these <em>ATXN3<\/em> lncRNAs:<\/p><ol><li>Are their levels different in three brain areas and between healthy controls and MJD patients?<\/li><li>Are they located in the nucleus, the cytoplasm, or both in the cells?<\/li><li>Do they interact with DNA, RNA, or proteins?<\/li><li>Is the normal function of these lncRNAs changed in the brain tissues of MJD patients?<\/li><\/ol><p>By the end of this project, we will be able to determine whether <em>ATXN3<\/em> lncRNAs vary in expression and interactions across brain regions with different levels of degeneration, potentially explaining why some regions are more vulnerable to the disease.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-5c9532a elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"5c9532a\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-a8bf3a5\" data-id=\"a8bf3a5\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-c60f206 elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"c60f206\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-2632511 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"2632511\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-b859798\" data-id=\"b859798\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-f30036d elementor-widget elementor-widget-heading\" data-id=\"f30036d\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">Post-Doctoral Fellowship Fellowship<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-7a302a6 elementor-widget elementor-widget-text-editor\" data-id=\"7a302a6\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>$35,000 &#8211; 1-Year Grant<br \/>12 LOIs Received | 7 Full Applications Reviewed | 3 Funded<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-1bedc32 elementor-widget elementor-widget-spacer\" data-id=\"1bedc32\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-311a73d elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"311a73d\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-33 elementor-top-column elementor-element elementor-element-b4a64d1\" data-id=\"b4a64d1\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-8fbe961 elementor-widget elementor-widget-image\" data-id=\"8fbe961\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"400\" height=\"500\" src=\"https:\/\/www.ataxia.org\/wp-content\/uploads\/2025\/03\/Luis-Almaguer-Sized.png\" class=\"attachment-large size-large wp-image-25874\" alt=\"\" srcset=\"https:\/\/www.ataxia.org\/wp-content\/uploads\/2025\/03\/Luis-Almaguer-Sized.png 400w, https:\/\/www.ataxia.org\/wp-content\/uploads\/2025\/03\/Luis-Almaguer-Sized-240x300.png 240w\" sizes=\"(max-width: 400px) 100vw, 400px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-39264e0 elementor-widget elementor-widget-text-editor\" data-id=\"39264e0\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"color: #005587;\"><b>Dr. Luis Almaguer Mederos<br \/><\/b><\/span>University College London Institute of Neurology <br \/><br \/><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-66 elementor-top-column elementor-element elementor-element-f0797c8\" data-id=\"f0797c8\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-f4fd087 elementor-widget elementor-widget-text-editor\" data-id=\"f4fd087\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>Research Title:<\/strong><em> Investigating Genetic Modifiers of SCA2<br \/><\/em><\/p><p><b>Ataxia Type: <\/b>SCA2<\/p><p>Spinocerebellar ataxia type 2 (SCA2) is a disease that affects the nervous system, and there are no preventive treatments. Our project seeks to identify genetic variants that explain the severity of disease manifestations using a Genome-Wide Association Study in a large international cohort of patients with SCA2. Identifying disease-modifying genetic variants will allow us to get deeper into the mechanisms of disease, recognize potential molecular markers of disease severity that might be useful to predict the course of disease and to stratify patients when testing potential therapies in clinical trials, improve genetic counseling in affected families, identify potential therapeutic targets and provide critical information for developing effective and targeted therapies to treat affected patients and at-risk family members.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-fe96545 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"fe96545\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-f2c1cb6\" data-id=\"f2c1cb6\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-760280f elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"760280f\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-1db0f76 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"1db0f76\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-33 elementor-top-column elementor-element elementor-element-7914555\" data-id=\"7914555\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-4ec2885 elementor-widget elementor-widget-image\" data-id=\"4ec2885\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"400\" height=\"500\" src=\"https:\/\/www.ataxia.org\/wp-content\/uploads\/2025\/03\/Michael-Almeida-Sized.png\" class=\"attachment-large size-large wp-image-25877\" alt=\"\" srcset=\"https:\/\/www.ataxia.org\/wp-content\/uploads\/2025\/03\/Michael-Almeida-Sized.png 400w, https:\/\/www.ataxia.org\/wp-content\/uploads\/2025\/03\/Michael-Almeida-Sized-240x300.png 240w\" sizes=\"(max-width: 400px) 100vw, 400px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-05b8126 elementor-widget elementor-widget-text-editor\" data-id=\"05b8126\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"color: #005587;\"><b>Dr. Michael Almeida<br \/><\/b><\/span>University of North Carolina at Chapel Hill <br \/><br \/><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-66 elementor-top-column elementor-element elementor-element-7769927\" data-id=\"7769927\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-6f1d683 elementor-widget elementor-widget-text-editor\" data-id=\"6f1d683\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>Research Title:<\/strong><em> CHIP in Spinocerebellar Ataxias: Unraveling Cellular Distribution, Disease Mechanisms, and Neuroprotective Roles<br \/><\/em><\/p><p><b>Ataxia Type: <\/b>SCA17\/SCA48<\/p><p>Spinocerebellar ataxias (SCAs) are rare genetic disorders that impair coordination and movement due to cerebellar damage. This project investigates the role of CHIP, a protein involved in cellular protection, and how its mutations contribute to disease progression by disrupting its normal localization and function. <br \/>Using advanced imaging techniques, the study aims to uncover how CHIP&#8217;s dynamic distribution changes in healthy versus diseased brain cells, potentially leading to new therapeutic strategies for SCAs.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-8bdd379 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"8bdd379\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-4402780\" data-id=\"4402780\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-0cd40f8 elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"0cd40f8\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-c59de0a elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"c59de0a\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-33 elementor-top-column elementor-element elementor-element-d492928\" data-id=\"d492928\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-3b66d25 elementor-widget elementor-widget-image\" data-id=\"3b66d25\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"400\" height=\"500\" src=\"https:\/\/www.ataxia.org\/wp-content\/uploads\/2025\/03\/Gonclaves-Sized.png\" class=\"attachment-large size-large wp-image-25881\" alt=\"\" srcset=\"https:\/\/www.ataxia.org\/wp-content\/uploads\/2025\/03\/Gonclaves-Sized.png 400w, https:\/\/www.ataxia.org\/wp-content\/uploads\/2025\/03\/Gonclaves-Sized-240x300.png 240w\" sizes=\"(max-width: 400px) 100vw, 400px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-973cf6f elementor-widget elementor-widget-text-editor\" data-id=\"973cf6f\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"color: #005587;\"><b>Dr. D\u00e9bora Farina Gon\u00e7alves<br \/><\/b><\/span>Claude Bernard University Lyon 1 <br \/><br \/><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-66 elementor-top-column elementor-element elementor-element-aa91ee0\" data-id=\"aa91ee0\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-662626b elementor-widget elementor-widget-text-editor\" data-id=\"662626b\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>Research Title:<\/strong><em> Sulfide metabolism as a therapeutical target for autosomal recessive ataxia type 2 (ARCA2) <\/em><\/p><p><b>Ataxia Type: <\/b>ARCA2<\/p><p>Autosomal recessive cerebellar ataxia type 2 (ARCA2), or COQ8A-ataxia, is a rare genetic disorder that leads to progressive symptoms such as balance difficulties, muscle weakness, seizures, and intellectual disability. This condition is caused by mutations in the COQ8A gene, which is crucial for producing Coenzyme Q10 (CoQ), a molecule necessary for energy production in cells and hydrogen sulfide (H2S) oxidation. A deficiency in CoQ damages brain cells, particularly Purkinje neurons (PN), which are vital for movement control. Our findings suggest that an early increase in hydrogen sulfide (H2S) may contribute to PN damage by disrupting energy production and causing mitochondrial dysfunction. Currently, no effective treatments are available for COQ8A-ataxia. Since CoQ is essential for the oxidation of H2S in cells, we aim to explore innovative ways to deliver CoQ to the brain using nanoparticles and develop strategies to reduce H2S toxicity using specific scavengers. This research aims to understand how H2S accumulation affects PN in COQ8A-ataxia and test potential treatments, which could benefit not only COQ8A-ataxia patients but also individuals with other CoQ deficiency-related diseases.<\/p><ul><li>COQ8A-ataxia is a rare genetic disorder, leading to symptoms like balance issues, muscle weakness, and seizures.<\/li><li>This condition is caused by mutations in the COQ8A gene, which is crucial for producing Coenzyme Q10 (CoQ).<\/li><li>COQ8A-ataxia damages particularly Purkinje neurons, by disrupting energy production.<\/li><li>A toxic accumulation of hydrogen sulfide (H2S) at early disease stages may contribute to PN damage.<\/li><li>Since oxidation of H2S is dependent of CoQ levels, we aim to improve CoQ delivery to the brain using nanoparticles and explore strategies to reduce H2S toxicity using specific scavengers.<\/li><li>This work could offer potential treatments for COQ8A-ataxia and other CoQ deficiency-related diseases.<\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-ed625fb elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"ed625fb\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-180d598\" data-id=\"180d598\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-311c038 elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"311c038\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-5ad16c9 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"5ad16c9\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-bf52104\" data-id=\"bf52104\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-e9bcca1 elementor-widget elementor-widget-heading\" data-id=\"e9bcca1\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">Graduate Research Fellowship<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-b6c039c elementor-widget elementor-widget-text-editor\" data-id=\"b6c039c\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>$25,000 &#8211; 1-Year Grant<br \/>17 LOIs Received | 7 Full Applications Reviewed | 5 Funded<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-e036057 elementor-widget elementor-widget-spacer\" data-id=\"e036057\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-c3ebd28 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"c3ebd28\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-33 elementor-top-column elementor-element elementor-element-bb4f985\" data-id=\"bb4f985\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-da3abd4 elementor-widget elementor-widget-image\" data-id=\"da3abd4\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"400\" height=\"500\" src=\"https:\/\/www.ataxia.org\/wp-content\/uploads\/2025\/03\/Chase-Sized.png\" class=\"attachment-large size-large wp-image-25865\" alt=\"\" srcset=\"https:\/\/www.ataxia.org\/wp-content\/uploads\/2025\/03\/Chase-Sized.png 400w, https:\/\/www.ataxia.org\/wp-content\/uploads\/2025\/03\/Chase-Sized-240x300.png 240w\" sizes=\"(max-width: 400px) 100vw, 400px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-bca313b elementor-widget elementor-widget-text-editor\" data-id=\"bca313b\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"color: #005587;\"><b>Ms. Alison Chase<br \/><\/b><\/span>Yale University School of Medicine<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-66 elementor-top-column elementor-element elementor-element-dab2157\" data-id=\"dab2157\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-10dd46e elementor-widget elementor-widget-text-editor\" data-id=\"10dd46e\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>Research Title:<\/strong><em> Identifying the astroglia-mediated pathogenic mechanisms contributing to neuronal vulnerability in Spinocerebellar Ataxia Type 1 (SCA1) <br \/><\/em><\/p><p><b>Ataxia Type: <\/b>SCA1<\/p><p>Although Purkinje cell loss is the primary pathological hallmark of SCA1, other cell types, including glial &#8220;support&#8221; cells, express the mutant ATXN1 gene. While astroglia are the most abundant glial cell type in the brain, it remains unclear how they contribute to SCA1 pathology and progression. In this proposal, we have created a novel mouse model in which mutant ATXN1 is expressed selectively in astroglial populations. We plan to use this mouse model to uncover the molecular mechanisms by which astroglia affect the health of Purkinje cells and other neuronal subtypes in the context of SCA1. We hope this work will reveal new glial-specific targets that may be therapeutically beneficial in promoting neuronal health and preventing SCA1 disease progression.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-519c7c7 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"519c7c7\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-45c0e4a\" data-id=\"45c0e4a\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-a5e8bb6 elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"a5e8bb6\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-4bb7fd1 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"4bb7fd1\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-33 elementor-top-column elementor-element elementor-element-df788a6\" data-id=\"df788a6\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-0abbd13 elementor-widget elementor-widget-image\" data-id=\"0abbd13\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"400\" height=\"500\" src=\"https:\/\/www.ataxia.org\/wp-content\/uploads\/2025\/03\/Hailey-Napier-Sized.png\" class=\"attachment-large size-large wp-image-25872\" alt=\"\" srcset=\"https:\/\/www.ataxia.org\/wp-content\/uploads\/2025\/03\/Hailey-Napier-Sized.png 400w, https:\/\/www.ataxia.org\/wp-content\/uploads\/2025\/03\/Hailey-Napier-Sized-240x300.png 240w\" sizes=\"(max-width: 400px) 100vw, 400px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-219ccde elementor-widget elementor-widget-text-editor\" data-id=\"219ccde\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"color: #005587;\"><b>Ms. Hailey Collis Napier<br \/><\/b><\/span>Duke University <br \/><br \/><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-66 elementor-top-column elementor-element elementor-element-834e535\" data-id=\"834e535\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-7386dfa elementor-widget elementor-widget-text-editor\" data-id=\"7386dfa\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>Research Title:<\/strong><em> A Cross-Species Atlas of Purkinje Cell Subtypes to Identify Ataxia-Causing Genes <br \/><\/em><\/p><p><b>Ataxia Type: <\/b>SCA7<\/p><p>I\u2019m interested in Purkinje cells, a key brain cell type that is known to degenerate in Spinocerebellar Ataxia Type 7 (SCA7). My lab previously found that Purkinje cells in mouse models of SCA7 abnormally express hundreds of genes. The goals of my project are to better understand these dysregulated genes in SCA7, and to investigate how genes are regulated in Purkinje cells across many vertebrates. Similarities across species will help us to understand which findings in mouse models can be used to help human patients.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-6f96730 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"6f96730\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-9d493f9\" data-id=\"9d493f9\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-0d7397f elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"0d7397f\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-bb6fa63 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"bb6fa63\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-33 elementor-top-column elementor-element elementor-element-941fa05\" data-id=\"941fa05\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-54fa00f elementor-widget elementor-widget-image\" data-id=\"54fa00f\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"400\" height=\"500\" src=\"https:\/\/www.ataxia.org\/wp-content\/uploads\/2025\/03\/Fishburn-Sized.png\" class=\"attachment-large size-large wp-image-25867\" alt=\"\" srcset=\"https:\/\/www.ataxia.org\/wp-content\/uploads\/2025\/03\/Fishburn-Sized.png 400w, https:\/\/www.ataxia.org\/wp-content\/uploads\/2025\/03\/Fishburn-Sized-240x300.png 240w\" sizes=\"(max-width: 400px) 100vw, 400px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-30e83de elementor-widget elementor-widget-text-editor\" data-id=\"30e83de\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"color: #005587;\"><b>Ms. Judith Fishburn<br \/><\/b><\/span>The Regents of the University of California, Davis<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-66 elementor-top-column elementor-element elementor-element-659f200\" data-id=\"659f200\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-d50a910 elementor-widget elementor-widget-text-editor\" data-id=\"d50a910\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>Research Title:<\/strong><em> Dissecting the role of innate immune activation and reactive oxygen species in ataxia with oculomotor apraxia type 2 (AOA2) <br \/><\/em><\/p><p><b>Ataxia Type: <\/b>AOA2<\/p><p>Our research aims to determine how DNA damage and reactive oxygen species (ROS) contribute to innate immune activation and oxidative damage in ataxia with oculomotor apraxia type 2 (AOA2) models and patient-derived cells. How these molecular phenotypes contribute to AOA2 disease phenotypes remains unknown, especially ROS given our lab recently identified this phenotype in an AOA2 mammalian model. Finally, this work will identify contributory pathways to disease etiology that are not well understood in AOA2, providing further insight into potential biomarkers for therapeutic targets.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-7fecb7a elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"7fecb7a\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-9eb6309\" data-id=\"9eb6309\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-1109efe elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"1109efe\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-4c484b4 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"4c484b4\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-33 elementor-top-column elementor-element elementor-element-9042ef7\" data-id=\"9042ef7\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-33240bd elementor-widget elementor-widget-image\" data-id=\"33240bd\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"400\" height=\"500\" src=\"https:\/\/www.ataxia.org\/wp-content\/uploads\/2025\/03\/Hailey-Napier-Sized-1.png\" class=\"attachment-large size-large wp-image-25871\" alt=\"\" srcset=\"https:\/\/www.ataxia.org\/wp-content\/uploads\/2025\/03\/Hailey-Napier-Sized-1.png 400w, https:\/\/www.ataxia.org\/wp-content\/uploads\/2025\/03\/Hailey-Napier-Sized-1-240x300.png 240w\" sizes=\"(max-width: 400px) 100vw, 400px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-186a637 elementor-widget elementor-widget-text-editor\" data-id=\"186a637\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"color: #005587;\"><b>Mr. Nolan Huck<br \/><\/b><\/span>The Regents of the University of California, Irvine<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-66 elementor-top-column elementor-element elementor-element-67ba649\" data-id=\"67ba649\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-0643fcf elementor-widget elementor-widget-text-editor\" data-id=\"0643fcf\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>Research Title:<\/strong><em> Multiomic Investigation of SCA7 Retinal Degeneration: Linking Transcriptional and Epigenomic Dysregulation <br \/><\/em><\/p><p><b>Ataxia Type: <\/b>SCA7<\/p><p>Spinocerebellar Ataxia type 7 (SCA7) causes progressive vision loss and impaired motor coordination. Unlike other ataxias, SCA7 uniquely affects the retina, leading to cone-rod dystrophy, a condition where patients lose color and low-light vision before progressing to complete blindness. This disease is caused by a mutation in the ATXN7 gene, which disrupts gene regulation in retinal cells, but the precise mechanisms driving retinal degeneration remain unclear. Our research will use single-cell and spatial technologies to investigate how SCA7 alters gene activity and DNA organization within the retina. By mapping these changes at the level of individual cells, we aim to pinpoint key molecular pathways driving retinal dysfunction. This work will provide new insights into SCA7 disease progression and help identify potential therapeutic targets to preserve vision in affected individuals.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-b79c204 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"b79c204\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-acbaca2\" data-id=\"acbaca2\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-81bc033 elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"81bc033\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-a225474 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"a225474\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-33 elementor-top-column elementor-element elementor-element-d992fa1\" data-id=\"d992fa1\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-29d644a elementor-widget elementor-widget-image\" data-id=\"29d644a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"400\" height=\"500\" src=\"https:\/\/www.ataxia.org\/wp-content\/uploads\/2025\/03\/Emily-Timm-Sized.png\" class=\"attachment-large size-large wp-image-25866\" alt=\"\" srcset=\"https:\/\/www.ataxia.org\/wp-content\/uploads\/2025\/03\/Emily-Timm-Sized.png 400w, https:\/\/www.ataxia.org\/wp-content\/uploads\/2025\/03\/Emily-Timm-Sized-240x300.png 240w\" sizes=\"(max-width: 400px) 100vw, 400px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-b3bcae8 elementor-widget elementor-widget-text-editor\" data-id=\"b3bcae8\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"color: #005587;\"><b>Ms. Emily Timm<br \/><\/b><\/span>Rush University Medical Center<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-66 elementor-top-column elementor-element elementor-element-bebf504\" data-id=\"bebf504\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-8bdc950 elementor-widget elementor-widget-text-editor\" data-id=\"8bdc950\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>Research Title:<\/strong><em> The neural mechanisms underlying cortical control of gait and cognition in Fragile X-Associated Tremor\/Ataxia Syndrome <br \/><\/em><\/p><p><b>Ataxia Type: <\/b>FXTAS<\/p><p>Fragile X-Associated Tremor\/Ataxia Syndrome (FXTAS) is characterized by cognitive and cerebellar motor dysfunction causing mobility impairment, increased fall risk, and poor quality of life. Executive function deficits and dual tasking in FXTAS negatively impact gait, but a critical knowledge gap exists for neural mechanisms underlying these cognitive-motor relationships, which impedes development of rational treatment strategies. The fundamental goals of my project are to: 1) elucidate cortical activation patterns in FXTAS during walking and executive function tasks of varying difficulty using wireless functional near infrared spectroscopy (fNIRS) technology, 2) measure grey matter volume (GMV) in the prefrontal cortex, motor planning regions, and the cerebellum, white matter integrity (WMI) of frontal-cerebellar networks, and 3) associate GMV and WMI with cortical activation during simple and complex gait and executive function tasks, as well as spatiotemporal aspects of gait and executive function test scores.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-c3c0dd1 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"c3c0dd1\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-5bfd365\" data-id=\"5bfd365\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-e76c3cf elementor-widget elementor-widget-spacer\" data-id=\"e76c3cf\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-d76750d elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"d76750d\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-50367c9 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"50367c9\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t\t<div class=\"elementor-background-overlay\"><\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-419a35b\" data-id=\"419a35b\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-b9d19b5 elementor-widget elementor-widget-heading\" data-id=\"b9d19b5\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">View Past Years Funded Research<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-2a30bf3 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"2a30bf3\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t\t<div class=\"elementor-background-overlay\"><\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-20 elementor-top-column elementor-element elementor-element-a08faf0\" data-id=\"a08faf0\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-aa4acc4 elementor-widget elementor-widget-heading\" data-id=\"aa4acc4\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\"><a href=\"https:\/\/www.ataxia.org\/2022-naf-funded-research\/\" target=\"_blank\">2024<\/a><\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-439724d elementor-widget elementor-widget-text-editor\" data-id=\"439724d\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"text-decoration: underline;\"><a href=\"https:\/\/www.ataxia.org\/2024-naf-research-grants\/\" target=\"_blank\" rel=\"noopener\">Funded Research<\/a><\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-20 elementor-top-column elementor-element elementor-element-ee16d16\" data-id=\"ee16d16\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-2e82bd5 elementor-widget elementor-widget-heading\" data-id=\"2e82bd5\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\"><a href=\"https:\/\/www.ataxia.org\/2022-naf-funded-research\/\" target=\"_blank\">2023<\/a><\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-bc06276 elementor-widget elementor-widget-text-editor\" data-id=\"bc06276\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"text-decoration: underline;\"><a href=\"https:\/\/www.ataxia.org\/2023-funded-research\/\" target=\"_blank\" rel=\"noopener\">Funded Research<\/a><\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-20 elementor-top-column elementor-element elementor-element-e138f5e\" data-id=\"e138f5e\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-cd1dbf2 elementor-widget elementor-widget-heading\" data-id=\"cd1dbf2\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\"><a href=\"https:\/\/www.ataxia.org\/2022-naf-funded-research\/\" target=\"_blank\">2022<\/a><\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-2682461 elementor-widget elementor-widget-text-editor\" data-id=\"2682461\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"text-decoration: underline;\"><a href=\"https:\/\/www.ataxia.org\/2022-naf-funded-research\/\" target=\"_blank\" rel=\"noopener\" data-wplink-edit=\"true\">Funded Research<\/a><\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-20 elementor-top-column elementor-element elementor-element-61bfe11\" data-id=\"61bfe11\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-6f512e5 elementor-widget elementor-widget-heading\" data-id=\"6f512e5\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\"><a href=\"https:\/\/www.ataxia.org\/2021-naf-funded-research\/\" target=\"_blank\">2021<\/a><\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-62e7e0d elementor-widget elementor-widget-text-editor\" data-id=\"62e7e0d\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"text-decoration: underline;\"><a href=\"https:\/\/www.ataxia.org\/2021-naf-funded-research\/\" target=\"_blank\" rel=\"noopener\">Funded Research<\/a><\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-20 elementor-top-column elementor-element elementor-element-54c764b\" data-id=\"54c764b\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-3fc2ec1 elementor-widget elementor-widget-heading\" data-id=\"3fc2ec1\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\"><a href=\"https:\/\/www.ataxia.org\/2020-naf-funded-research\/\" target=\"_blank\">2020<\/a><\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-7fd0742 elementor-widget elementor-widget-text-editor\" data-id=\"7fd0742\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"text-decoration: underline;\"><a href=\"https:\/\/www.ataxia.org\/2020-naf-funded-research\/\" target=\"_blank\" rel=\"noopener\">Funded Research<\/a><\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-6c5e6f4 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"6c5e6f4\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t\t<div class=\"elementor-background-overlay\"><\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-4f28b52\" data-id=\"4f28b52\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-c120a7c elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"c120a7c\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-7ad7757 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"7ad7757\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t\t<div class=\"elementor-background-overlay\"><\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-25 elementor-top-column elementor-element elementor-element-dbd5094\" data-id=\"dbd5094\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-85f25e4 elementor-widget elementor-widget-heading\" data-id=\"85f25e4\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\">2019<\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-c937e52 elementor-widget elementor-widget-text-editor\" data-id=\"c937e52\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"text-decoration: underline;\"><a href=\"https:\/\/www.ataxia.org\/2019-naf-funded-research-results\/\" target=\"_blank\" rel=\"noopener\">Funded Research<\/a><\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-25 elementor-top-column elementor-element elementor-element-8282439\" data-id=\"8282439\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-10ad5ab elementor-widget elementor-widget-heading\" data-id=\"10ad5ab\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\"><a href=\"https:\/\/www.ataxia.org\/naf-research\/research-2018\/\" target=\"_blank\">2018<\/a><\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-a8e3f27 elementor-widget elementor-widget-text-editor\" data-id=\"a8e3f27\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"text-decoration: underline;\"><a href=\"https:\/\/www.ataxia.org\/naf-research\/research-2018\/\" target=\"_blank\" rel=\"noopener\">Funded Research<\/a><\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-25 elementor-top-column elementor-element elementor-element-fc02c28\" data-id=\"fc02c28\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-71ddfa4 elementor-widget elementor-widget-heading\" data-id=\"71ddfa4\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\"><a href=\"https:\/\/www.ataxia.org\/naf-research\/research-2017\/\" target=\"_blank\">2017<\/a><\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-4b96db8 elementor-widget elementor-widget-text-editor\" data-id=\"4b96db8\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"text-decoration: underline;\"><a href=\"https:\/\/www.ataxia.org\/naf-research\/research-2017\/\" target=\"_blank\" rel=\"noopener\">Funded Research<\/a><\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-25 elementor-top-column elementor-element elementor-element-6ac5dea\" data-id=\"6ac5dea\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-24258e0 elementor-widget elementor-widget-heading\" data-id=\"24258e0\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\"><a href=\"https:\/\/www.ataxia.org\/naf-research\/research-2016\/\" target=\"_blank\">2016<\/a><\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-fd0acb6 elementor-widget elementor-widget-text-editor\" data-id=\"fd0acb6\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"text-decoration: underline;\"><a href=\"https:\/\/www.ataxia.org\/naf-research\/research-2016\/\" target=\"_blank\" rel=\"noopener\">Funded Research<\/a><\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-6498827 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"6498827\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-2076b5c\" data-id=\"2076b5c\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-6cb6805 elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"6cb6805\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t<div class=\"elementor-element elementor-element-26d1a65 e-flex e-con-boxed e-con e-parent\" data-id=\"26d1a65\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-720fb03 elementor-widget elementor-widget-spacer\" data-id=\"720fb03\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-6188790 elementor-widget elementor-widget-heading\" data-id=\"6188790\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">How Does the Research Grant Process Work?<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-92c76ac elementor-widget elementor-widget-text-editor\" data-id=\"92c76ac\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"color: var( --e-global-color-text ); font-family: var( --e-global-typography-text-font-family ), Sans-serif; text-align: var(--text-align);\">To receive an Ataxia research grant from NAF, researchers go through a 4-step process:<\/span><\/p><ol><li><strong>Submit a Letter of Intent (LOI) <\/strong>&#8211; This is a brief overview that gives information about the goal of their research study.<\/li><li><strong>LOIs are Reviewed<\/strong> &#8211; A panel of Ataxia experts review and score each LOI for scientific merit. They determine which LOIs will be invited to submit a grant application.<\/li><li><strong>Submit Grant Application<\/strong> &#8211; Studies which received a high enough score to move to the next step of the process are invited to submit a full application. The grant application requires more time and details about their project.<\/li><li><strong>Grants Applications Reviewed and Recommended for Funding<\/strong> &#8211; Each application receives 3 separate scientific reviews. NAF has 75 scientific reviewers who evaluate and score each full application that is received. Top-scoring grant applications are recommended for funding.\u00a0<\/li><\/ol><p>Thank you to all the researchers who submitted an LOI or application! Keep up the great work that is SO important to the Ataxia community!<\/p><p>\u00a0<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-c6e328c elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"c6e328c\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-65dcb86\" data-id=\"65dcb86\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-56dc99e elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"56dc99e\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>We&#8217;re proud to announce that we funded 18 research grants for 2025 totaling $730K!&nbsp; For the funding term of March 1, 2025 &#8211; February 28, 2026,&nbsp;NAF received 96 Letters of <a class=\"MoreInfo\" href=\"https:\/\/www.ataxia.org\/2025-naf-research-grants\/\">Read More&#8230;<\/a><\/p>\n","protected":false},"author":4,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[695,723],"tags":[],"class_list":["post-25859","post","type-post","status-publish","format-standard","hentry","category-naf","category-research"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.7 - 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